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    Relia Tech:活性VEGF,VEGFR重組蛋白

    發布者:艾美捷科技    發布時間:2022-07-26     

    新血管的形成(angiogenesis)是腫瘤生長轉移和傳播過程中的一種基本活動。因此,在癌癥研究領域,人們對研究腫瘤血管生成的分子機制十分感興趣。而血管內皮生長因子(vascular endothelial growth factor,VEGF)路徑是這一過程的關鍵調節者。   


    VEGF(vascular endothelial growth factor,血管內皮生長因子)/VEGFR(vascular endothelial growth factor receptor,血管內皮生長因子受體)軸由多重配基和受體質量疊加交錯組成,并且受體與配基結合具有專一性,在不同的細胞中具有不同的細胞類型表達和功能,啟動VEGFR信號通路,觸發了一個網狀的信號過程,從而促進血管內皮細胞生長、轉移和存活。VEGF/VEGFR也是目前研究最多的一條信號通路,并取得了顯著的成果。

    作為專業的生命科學醫藥原料和解決方案供應商,艾美捷科技為您推薦來自德國,Relia Tech榮譽出品:活性VEGF,VEGFR重組蛋白 

    RET-M30-032重組蛋白, 小鼠, VEGF120大腸桿菌20ug120Q00731
    RET-R20-064重組蛋白, 大鼠, VEGF120大腸桿菌20ug120P16612
    RET-300-072重組蛋白, 人, VEGF121大腸桿菌20ug121P15692
    RET-300-032重組蛋白, 人, VEGF121昆蟲細胞20ug121P15692
    RET-M30-034重組蛋白, 小鼠, VEGF144大腸桿菌20ug144Q00731
    RET-300-033S-E重組蛋白, 人, VEGF145大腸桿菌2ug145P15692
    RET-300-034-E重組蛋白, 人, VEGF145大腸桿菌20ug145P15692
    RET-M30-004重組蛋白, 小鼠, VEGF164大腸桿菌20ug164Q00731
    RET-M30-002重組蛋白, 小鼠, VEGF164昆蟲細胞20ug164Q00731
    RET-R20-068重組蛋白, 大鼠, VEGF164大腸桿菌20ug164P16612
    RET-300-076重組蛋白, 人, VEGF165大腸桿菌20ug164P15692
    RET-300-036重組蛋白, 人, VEGF165昆蟲細胞20ug165P15692
    RET-300-082重組蛋白, 人, VEGF165b大腸桿菌20ug164P15692-8
    RET-300-065Bi重組蛋白, 人, VEGF165-生物素大腸桿菌10ug165P15692
    RET-300-066Bi重組蛋白, 人, VEGF165-生物素大腸桿菌25ug165P15692
    RET-M30-095重組蛋白, 小鼠, VEGF188大腸桿菌20ug188Q00731
    RET-R20-070重組蛋白, 大鼠, VEGF188大腸桿菌20ug188P16612
    RET-300-095重組蛋白, 人, VEGF189大腸桿菌20ug189P15692
    RET-300-099重組蛋白, 人, VEGF206大腸桿菌20ug206P15692
    RET-300-080重組蛋白, 人, VEGF-B167大腸桿菌20ug167P49765
    RET-300-079重組蛋白, 人, VEGF-C昆蟲細胞20ug121P49767
    RET-R20-015重組蛋白, 大鼠, VEGF-C昆蟲細胞20ug127O35757
    RET-R20-017重組蛋白, 大鼠, VEGF-C152S昆蟲細胞20ug127O35757
    RET-300-045重組蛋白, 羊口瘡病毒, VEGF-E大腸桿菌20ug132Q9YMF3
    RET-300-046重組蛋白, 羊口瘡病毒,  VEGF-E,  肝素結合域昆蟲細胞20ug154Q9YMF3
    RET-300-097重組蛋白, 蛇,  VEGF-F (矛頭蝮)大腸桿菌20ug124Q90X24
    RET-S01-016重組蛋白, 人, VEGFR-1/Flt-1 (D3), 可溶性蛋白昆蟲細胞20ug327P17948
    RET-S01-080重組蛋白, 人, VEGFR-1/Flt-1 (D3)-His, 可溶性蛋白昆蟲細胞50ug327P17948
    RET-S01-014重組蛋白, 人, VEGFR-1/Flt-1 (D4), 可溶性蛋白昆蟲細胞20ug457P17948
    RET-S01-012重組蛋白, 人, VEGFR-1/Flt-1 (D5), 可溶性蛋白昆蟲細胞20ug536P17948
    RET-S01-010重組蛋白, 人, VEGFR-1/Flt-1(天然), 可溶性蛋白昆蟲細胞20ug661P17948
    RET-S01-072重組蛋白, 人, VEGFR1-14/Flt1-14, 可溶性蛋白昆蟲細胞20ug707P17948-3
    RET-SFC-006重組蛋白, 人, VEGFR-1/Flt-1(D7)-Fc 嵌合體, 可溶性蛋白昆蟲細胞50ug954P17948
    RET-SFC-M06重組蛋白, 小鼠, VEGFR-1/Flt-1(D7)-Fc 嵌合體, 可溶性蛋白昆蟲細胞50ug965P17948
    RET-S01-002重組蛋白, 人, VEGFR-2/KDR (D7), 可溶性蛋白昆蟲細胞50ug738P35968
    RET-S01-004重組蛋白, 人, VEGFR-2/KDR(天然), 可溶性蛋白昆蟲細胞20ug659P35968
    RET-SFC-008重組蛋白, 人, VEGFR-2/KDR-Fc 嵌合體, 可溶性蛋白昆蟲細胞50ug968P35968
    RET-S01-M04重組蛋白, 小鼠, VEGFR-2/Flk-1(天然), 可溶性蛋白昆蟲細胞20ug654P35918
    RET-S01-018重組蛋白, 人, VEGFR-3/FLT-4, 可溶性蛋白昆蟲細胞50ug761P35916
    RET-SFC-010重組蛋白, 人, VEGFR-3/FLT-4/Fc 嵌合體, 可溶性蛋白昆蟲細胞50ug979P35916

    * 以上蛋白產品,均為凍干粉形式.* 蛋白分子量與序列詳情,歡迎垂詢艾美捷客服. 



    • Cudmore, M., Hewett, P., Ahmad, S. et al. The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun 3, 972 (2012). https://doi.org/10.1038/ncomms1977

    • Teichert, M., Milde, L., Holm, A. et al. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun 8, 16106 (2017). https://doi.org/10.1038/ncomms16106

    • SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes. R. Atallah et al., Int J Mol Sci. 2021 Nov; 22(21): 12048.

    • Transforming growth factor‐β1 signalling triggers vascular endothelial growth factor resistance and monocyte dysfunction in type 2 diabetes mellitus. L.‐M. Makowski et al., J Cell Mol Med. 2021 Jun; 25(11): 5316–5325.

    • Outgrowth, proliferation, viability, angiogenesis and phenotype of primary human endothelial cells in different purchasable endothelial culture media: feed wisely. B. Leopold et al., Histochem Cell Biol. 2019; 152(5): 377–390.

    • Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Qi Chen et al., Cell Stem Cell. 2019 Dec 5; 25(6): 768–783.e6.

    • BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation. E. Pardali et al., J Cell Mol Med. 2018 Nov;22(11):5429-5438.

    • Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential.  Tasev D et al., Front Med (Lausanne). 2018 Dec 20;5:356.

    • Blood Outgrowth and Proliferation of Endothelial Colony Forming Cells are Related to Markers of Disease Severity in Patients with Pulmonary Arterial Hypertension. Smits J et al., Int J Mol Sci. 2018 Nov 27;19(12). pii: E3763.

    • Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. H. M. Eilken et al., Nat Commun. 2017; 8: 1574.

    • CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs). D. Tasev et al., Angiogenesis. 2016; 19: 325–338.

    • Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature. Lohr J et al., Anticancer Res. 2015 May;35(5):2681-90.

    • Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity. D. Tasev et al., PLoS One. 2015; 10(6): e0129935.

    • The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib?). A. K.A. Gaumann et al., Int J Oncol. 2014 Dec; 45(6): 2267–2277.

    • Improved Anchorage of Ti6Al4V Orthopaedic Bone Implants through Oligonucleotide Mediated Immobilization of BMP-2 in Osteoporotic Rats. J. V. W?lfle et al., PLoS One. 2014; 9(1): e86151.

    • Spatial regulation of VEGF receptor endocytosis in angiogenesis. M. Nakayama et al., Nat Cell Biol.2 13 Mar; 15(3): 249–260.

    • Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity. N. Izumi et al., PLoS One. 2012; 7(7): e41116.

    • The Antiangiogenic 16K Prolactin Impairs Functional Tumor Neovascularization by Inhibiting Vessel Maturation. Ngoc-Quynh-Nhu Nguyen et al., PLoS One. 2011; 6(11): e27318.

    • MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells. C. Sabatel et al., PLoS One. 2011; 6(2): e16979.

    • Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis. S. Ahmad et al., Vasc Cell. 2011; 3: 15.

    • Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit: THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS. V. Caolo et al., J Biol Chem. 2010 Dec 24; 285(52): 40681–40689.

    • Impaired Collateral Recruitment and Outward Remodeling in Experimental Diabetes. J. M. van Golde et al., Diabetes. 2008 Oct; 57(10): 2818–2823.

    • Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. S. Ahmad and A. Ahmed Circ Res. 2004 Oct 29;95(9):884-91.

    • Collagen type 1 retards tube formation by human microvascular endothelial cells in a fibrin matrix. Kroon, M.E. et al., Angiogenesis (2002) 5: 257.

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